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NTSAD - Glossary - GM2 Ganglioside

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Tay-Sachs, Canavan, GM1 and Sandhoff diseases

GM2 Ganglioside

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Term Definition
GM2 Ganglioside

A fatty substance or lipid that is part of normal metabolism, in Tay-Sachs and Sandhoff lack of enzyme function causes the GM2 gangliosides to accumulate which is toxic and eventually causes cell death.

Tay-Sachs and Sandhoff are known collectively as GM2.

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