NTSAD Grant Opportunities

Learn More about Funding for Research on Tay-Sachs, Canavan, GM1 Gangliosidosis, and Sandhoff Diseases

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NTSAD Research Initiative Program Launched
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NTSAD Research Initiative Projects Awarded
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Million in Grant Contributions Awarded

Since its inception in 2002, the National Tay-Sachs & Allied Diseases Association (NTSAD) Research Initiative has awarded more than 74 grants and provided more than $4.7 million in funding. The data generated in some of these projects funded by NTSAD grant opportunities were leveraged to obtain future funding from larger National Institutes of Health (NIH) grants, resulting in over $10 million toward finding cures.

Research Initiative Program

The NTSAD Research Initiative program funds cutting-edge research to find treatments and cures for Tay-Sachs, Canavan, GM1 gangliosidosis, and Sandhoff diseases. Investigators who work on projects relevant to our mission are encouraged to apply for NTSAD grant opportunities. Proposals are evaluated by members of our Scientific Advisory Council (SAC) and the Research Committee, which is made up of our Community members.

Current NTSAD Grant Opportunities

Annual Request for Proposals

Every autumn, we issue a Request for Proposals (RFP) for innovative research projects that study Tay-Sachs, Canavan, GM1, and Sandhoff diseases. During some grant cycles, we highlight particular areas of funding interest, such as translational and clinical studies.

Note: The new grant cycle will open in fall 2024 and further details will be posted here at that time.

Off-Cycle Grants

NTSAD also supports off-cycle grants, travel awards, and special projects that fit within our research priorities.

If you are conducting research related to Tay-Sachs, Canavan, GM1, or Sandhoff diseases, please contact our Research Director, Valerie Greger (vgreger@ntsad.org) about submitting a proposal for NTSAD grant opportunities.

2024 Grant Recipients

Amanda Gross, PhD, Auburn University, and Jessica Larsen, PhD, Clemson University

Project
Nanoparticle Distributed Intravenous Enzyme Replacement Therapy (NanoDIVERT) for Tay-Sachs and Sandhoff diseases

Project Type
Basic Research

Angela Gritti, PhD, IRCCS, Ospedale San Raffaele

Project
Enhancing the therapeutic potential of hematopoietic stem cell gene therapy to treat GM2 gangliosidosis (Tay-Sachs and Sandhoff)

Project Type
Gene and Cell Therapy

Past Grant Recipients

Discover the innovative Research Initiative program grants funded in prior cycles. Download the complete list of grant recipients since 2002.

Year Investigators Project Type of Project
2023 Amanda Nagy, MD and Florian Eichler, MD
Massachusetts General Hospital
Characterization of Progressive Neuroimaging and Pathologic Changes in Canavan Disease n/a
2023 Jennifer Kwon, MD and Julie Kissell, PhD candidate
University of Wisconsin
Development of a Disease-Specific Clinical Rating Scale for the Late-Onset GM2 Gangliosidoses n/a
2023 Dominic Gessler, MD and Guangping Gao, PhD
UMass Medical
Non-Invasive MRI-based Therapeutic Outcome Prediction Modeling Using Machine Learning n/a
2022 Elise Townsend, DPT, PhD, PCS
Massachusetts General Hospital
Construction and Validation of the Infantile GM2 Rating Scale Clinical Trial Readiness
2022 Amanda Gross, PhD
Auburn University
Dual Site Administration of AAV Gene Therapy for the Treatment of Feline GM1 Gangliosidosis Gene Therapy
2022 Michael Gelb, PhD & Hamid Khaledi, PhD
GelbChem
Newborn Screening Assay Development (bridge grant) Diagnostics
2018 Tony Futerman, PhD
Weizmann Institute of Science, Israel
Role of microglia in Sandhoff disease pathology Basic Research
2018 Alessandra d’Azzo, PhD
St. Jude Children’s Research Hospital
Role of the Plasma membrae-ER Contact Sites in GM1-mediated Neuronal Cell Death Basic Research
2018 Xuntian Jiang, PhD
Washington University
Oligosaccharide Biomarkers for Disease Progression and AAV Therapeutic Efficacy in GM1 Gangliosidosis Biomarkers
2017 Miguel Sena-Esteves, PhD
U Massachusetts Medical Center
Accelerated program for CSF delivery of AAV gene therapy for Tay-Sachs and Sandhoff patients (off-cycle) Gene Therapy
2017 Miguel Sena-Esteves, PhD
U Massachusetts Medical Center
Amendment to 2015 grant for Pre-Clinical studies (off-cycle)
2017 Alessandra Biffi, MD
Children’s Hospital, Boston
Proof of concept study of HSC gene therapy for Tay-Sachs disease gene and cell therapy Gene and Cell Therapy
2017 Heather Gray-Edwards, PhD
Auburn University
Minimally invasive delivery of AAV gene therapy in the Tay-Sachs Sheep gene therapy Gene Therapy
2017 Tim Wood, PhD
Greenwood Genetic Center, SC
Stephane Demotz, PhD
Dorphan, Switzerland
Development of a quantitative method for the determination of a pentasaccharide in GM1-gangliosidosis patient cells to assess the potential therapeutic efficacy of a beta-galactosidase pharmacological chaperone drug candidate Biomarkers
2016 Beverly Davidson, PhD
Children’s Hospital, Philadelphia
Identifying Novel Therapeutics for Treating GM2 Gangliosidoses Gene and Cell Therapy
2016 Angela Gritti, PhD
San Raffaele Scientific Institute, Italy
Novel combined gene-cell therapy strategies to provide full rescue of the Sandhoff pathological phenotype